This question begins and ends with the terms of her lease. What does it say? It’s a legal contract and she is bound by its conditions.
However, if she is so valuable to the property, the landlord needs to start thinking long term, rather than take it or leave it.
Perhaps the landlord could offer her another larger property within the complex – or a satellite space.
Failing that, I’d be tempted to talk about sub-letting or expanding the business to include a tattoo parlour and “dope” shop while moving the core business elsewhere.
Maybe that would focus the landlord’s thinking.